Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.32 |
| ▸ | TRPV2 | Q9Y5S1 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293466 | 0.85 | KDM4E (0.34) | SLC6A2HTR1AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7298544 | 0.80 | HTR2C (0.44) | HTR2CMAOBCA12CA9 | |
| SCHEMBL7293318 | 0.80 | HTR2C (0.42) | HTR2CKDM4EHTTALDH1A1LMNA | |
| SCHEMBL7290026 | 0.80 | HTR2C (0.42) | HTR2CMAOB | |
| SCHEMBL9583438 | 0.77 | HTR2C (0.47) | HTR1AHTR2CHTR2BSIGMAR1TRPA1 | |
| SCHEMBL9583946 | 0.76 | DAO (0.33) | TRPV1LMNACA9TP53 | |
| SCHEMBL7300321 | 0.76 | ABCB1 (0.38) | KDM4ELMNAMAOBCA12CA9 | |
| SCHEMBL7299822 | 0.75 | AKR1B1 (0.43) | ALDH1A1LMNACA12CA9CYP3A4 | |
| SCHEMBL1707125 | 0.75 | MEN1 (0.40) | HTR2CHTR2BTP53 | |
| SCHEMBL3535518 | 0.74 | CYP3A4 (0.33) | KDM4EHTTALDH1A1MAOBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |