Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8947543 | 0.99 | F2 (0.40) | F2LMNAKCNA5TRPA1 | |
| SCHEMBL7300396 | 0.88 | F2 (0.49) | F2 | |
| Hydrochloric Acid SCHEMBL8947545 | 0.87 | F2 (0.49) | F2 | |
| SCHEMBL8947908 | 0.86 | F2 (0.36) | F2LMNAKCNA5TRPA1 | |
| SCHEMBL8719573 | 0.86 | F2 (0.36) | F2LMNAKCNA5TRPA1 | |
| SCHEMBL7304748 | 0.86 | F2 (0.36) | F2LMNAKCNA5TRPA1 | |
| SCHEMBL8947619 | 0.78 | F2 (0.45) | F2 | |
| SCHEMBL9002951 | 0.77 | CYP1A2 (0.41) | — | |
| SCHEMBL7304323 | 0.76 | F2 (0.44) | F2 | |
| Hydrochloric Acid SCHEMBL8947627 | 0.76 | F2 (0.61) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | claimed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | claimed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5405854-A | Anticoagulants | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |