SCHEMBL7300636

SCHEMBL7300636

COc1c(OCCN2CCCCC2)c(C(C)=O)c(OCc2ccccc2)c2ccoc12

nearest known ligand 0.71

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 8/20 0.71
KCNA2 P16389 1/20 0.58
KCNA5 P22460 1/20 0.58
KCNA1 Q09470 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9830665 0.90 KCNA3 (0.71) KCNA3
SCHEMBL7289500 0.88 KCNA3 (0.62) KCNA3
SCHEMBL9830027 0.88 KCNA3 (0.62) KCNA3
SCHEMBL9830368 0.87 KCNA3 (0.64) KCNA3
SCHEMBL7292603 0.84 KCNA3 (0.58) KCNA3
SCHEMBL9830624 0.83 KCNA3 (0.64) KCNA3
SCHEMBL9830048 0.83 KCNA3 (0.54) KCNA3KCNA2KCNA5KCNA1
SCHEMBL9828058 0.81 KCNA3 (0.64) KCNA3
SCHEMBL3612048 0.80 KCNA3 (0.58) KCNA3
SCHEMBL13442788 0.80 KCNA3 (0.55) KCNA3KCNA2KCNA5KCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0284914-B1 BENZOFURAN DERIVATIVES AND THERAPEUTIC AGENTS CONTAINING THEM BASF Aktiengesellschaft (DE) 1991-10-16 EP disclosed
US-5039701-A Calcium antagonists for treatment of heart disease, vasospasms, hypertension BASF AKTIENGESELLSCHAFT (DE) 1991-08-13 US disclosed
US-4845096-A Benzofuran derivatives and antiulcerogenic agents containing same BASF AKTIENGSELLSCHAFT (DE) 1989-07-04 US disclosed
EP-0303920-A1 Benzofuran derivatives and therapeutic agents containing them BASF Aktiengesellschaft (DE) 1989-02-22 EP disclosed
EP-0284914-A1 Benzofuran derivatives and therapeutic agents containing them BASF Aktiengesellschaft (DE) 1988-10-05 EP disclosed