Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | VEGFA | P15692 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PDE1A | P54750 | 1/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293719 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL22562810 | 0.84 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL13677704 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL22562815 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9792208 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3541828 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL18117803 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9647066 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL19559499 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL23118946 | 0.81 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350437-B1 | 3,4-Disubstituted phenyl-heterocycles and their use | SCHERING AG (DE) | 1995-09-06 | — | — | EP | disclosed |
| US-5064854-A | 3,4-DISUBSTITUTED PHENYL HETEROCYCLES AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-12 | — | — | US | disclosed |
| EP-0350437-A1 | 3,4-Disubstituted phenyl-heterocycles and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-10 | — | — | EP | disclosed |