Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300739 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2HIF1ANPC1LMNARAB9A | |
| SCHEMBL7300913 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2HIF1ANPC1LMNARAB9A | |
| SCHEMBL7300908 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2HIF1ANPC1LMNARAB9A | |
| SCHEMBL7609842 | 0.82 | PTPN1 (0.43) | SMN1; SMN2NPC1LMNARAB9APTPN1 | |
| SCHEMBL3914141 | 0.82 | ESR1 (0.50) | SMN1; SMN2HIF1ACETPKIF11 | |
| SCHEMBL10424311 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2HIF1ACETPCYP1A2PPARA | |
| SCHEMBL28762466 | 0.77 | PPARA (0.43) | SMN1; SMN2NPC1LMNARAB9APTPN1 | |
| SCHEMBL10867877 | 0.76 | PTPN1 (0.45) | SMN1; SMN2HIF1ALMNAPTPN1SLC13A5 | |
| SCHEMBL7607399 | 0.75 | PTPN1 (0.47) | SMN1; SMN2NPC1LMNARAB9APTPN1 | |
| Bicarbonate SCHEMBL10586527 | 0.73 | CNR1 (0.44) | SMN1; SMN2NPC1LMNARAB9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |