Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pantothenic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | VNN1 | O95497 | 13/20 | 0.52 |
| ▸ | ECE1 | P42892 | 3/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pantothenic Acid, Racemic SCHEMBL11010633 | 0.94 | PTGS1 (0.56) | PTGS1KCNH2VNN1ECE1ZDHHC20 | |
| Pantothenic Acid SCHEMBL11010628 | 0.94 | PTGS1 (0.56) | PTGS1KCNH2VNN1ECE1ZDHHC20 | |
| Pantothenic Acid, Racemic SCHEMBL28332288 | 0.90 | PTGS1 (0.56) | PTGS1KCNH2VNN1ECE1ZDHHC20 | |
| Pantothenic Acid SCHEMBL29872649 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid SCHEMBL7016631 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid, Racemic SCHEMBL5437 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid SCHEMBL21547 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid, Racemic SCHEMBL21114380 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid SCHEMBL14126322 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 | |
| Pantothenic Acid SCHEMBL5436 | 0.89 | PTGS1 (0.67) | PTGS1KCNH2VNN1ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679084-A4 | — | — | 1995-11-08 | — | — | EP | disclosed |
| EP-0679084-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO. INC. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994014438-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO., INC. (US) | 1994-07-07 | — | — | WO | disclosed |
| US-5137904-A | Useful in the treatment of atherosclerosis and thrombosis | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0486280-A2 | Piperidinylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| WO-1992007821-A1 | DIASTEREOISOMERS OF BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |