Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299787 | 0.86 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301992 | 0.84 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7293459 | 0.83 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301640 | 0.82 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7293182 | 0.81 | BACE1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7296546 | 0.80 | APP (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7302109 | 0.79 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7302352 | 0.78 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301536 | 0.78 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7294584 | 0.78 | PSEN1 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |