Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278655 | 0.91 | ABL1 (0.60) | ABL1ABCB1BCRHDAC4HDAC2 | |
| SCHEMBL3282910 | 0.85 | CYP1A2 (0.50) | SLC6A4SLC6A3NPC1RAB9ATP53 | |
| SCHEMBL7302636 | 0.84 | ABL1 (0.46) | ABL1ABCB1BCRHSP90AA1HSP90AB1 | |
| SCHEMBL29114233 | 0.83 | CYP1A2 (0.48) | HSP90AA1HSP90AB1SLC6A4SLC6A3NPC1 | |
| Acetic Acid SCHEMBL28322406 | 0.77 | SLC6A4 (0.50) | HSP90AA1HSP90AB1SLC6A4SLC6A3MAPT | |
| SCHEMBL3947663 | 0.77 | HPGD (0.59) | ABL1ABCB1BCRGLANPC1 | |
| SCHEMBL12715050 | 0.77 | ABL1 (0.79) | ABL1ABCB1BCRAURKBHDAC4 | |
| SCHEMBL28841013 | 0.76 | GSTP1 (0.59) | ABL1ABCB1BCRNPC1RAB9A | |
| SCHEMBL5681041 | 0.76 | ABL1 (0.60) | ABL1ABCB1BCRHDAC4HDAC2 | |
| SCHEMBL6267998 | 0.75 | ABL1 (0.50) | ABL1ABCB1BCRHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |