Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303724 | 0.90 | RAD52 (0.43) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL7302713 | 0.72 | MAPT (0.66) | MAPTKMT2AMEN1GPR119PDE3B | |
| SCHEMBL7293313 | 0.71 | RAD52 (0.50) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL12647765 | 0.70 | MAPT (0.50) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL10773538 | 0.70 | PDE3B (0.42) | MAPTKMT2APKMMEN1KDM4E | |
| SCHEMBL1974375 | 0.69 | RAD52 (0.67) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL19383787 | 0.69 | IDO1 (1.00) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL1971897 | 0.69 | KMT2A (0.78) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL12647369 | 0.68 | MAPT (0.57) | RAD52UBE2NIDO1MAPTKMT2A | |
| SCHEMBL27624079 | 0.68 | PDE4A (0.48) | MAPTKMT2AMEN1GPR119PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |