SCHEMBL7304151

SCHEMBL7304151

CC(C)(C)OC(=O)N1CCCC(CCCN2CCC(NC(=O)C(C)(C)C)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 13/20 0.58
TACR2 P21452 12/20 0.58
TACR3 P29371 8/20 0.58
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CCR5 P51681 6/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7303394 0.89 TACR2 (0.73) TACR1TACR2TACR3CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL7751635 0.88 TACR2 (0.72) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL6543284 0.86 TACR2 (0.66) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL7307364 0.85 TACR2 (0.77) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL7305689 0.83 TACR2 (0.51) TACR1TACR2TACR3CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL8012872 0.82 TACR2 (0.50) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL7465937 0.80 TACR2 (0.53) TACR1TACR2TACR3CCR5
SCHEMBL24855513 0.80 TACR2 (0.79) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL7307760 0.80 TACR2 (0.79) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL31224303 0.80 TACR2 (0.79) TACR1TACR2TACR3CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294537-B1 NEUROKININS USED FOR TREATMENT OF DISEASES SANOFI-SYNTHELABO (FR) 2001-09-25 US disclosed
EP-0673928-B1 Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists SANOFI SYNTHELABO (FR) 2001-08-29 EP disclosed
US-6124316-A ACTIVE DRUG TREATING PSYCHIATRIC DISEASES, DISEASES OF PSYCHOSOMATIC ORIGIN, OF HYPERTENSION AND, NERVOUS SYSTEM DISORDERS SANOFI (FR) 2000-09-26 US disclosed
US-5942523-A NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES SANOFI (FR) 1999-08-24 US disclosed
US-5741910-A PIPERIDINE DERIVATIVE INTERMEDIATES SANOFI (FR) 1998-04-21 US disclosed
EP-0673928-A1 Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists SANOFI (FR) 1995-09-27 EP disclosed