Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1914 | 0.75 | ADORA2A (0.41) | ADORA2AADORA1YTHDC1CDK1DYRK1A | |
| SCHEMBL1997511 | 0.72 | ADORA2A (0.32) | ADORA2AADORA1YTHDC1 | |
| SCHEMBL360582 | 0.67 | — | — | |
| SCHEMBL19059638 | 0.64 | — | — | |
| SCHEMBL5387153 | 0.64 | — | — | |
| SCHEMBL15842953 | 0.63 | — | — | |
| SCHEMBL21719978 | 0.61 | KDM4E (0.42) | KDM4EYTHDC1CDK1 | |
| SCHEMBL14732773 | 0.61 | KDM4E (0.42) | KDM4EYTHDC1CDK1 | |
| SCHEMBL8326360 | 0.61 | — | — | |
| SCHEMBL860591 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5177207-A | Cardiac failure, memory defecit | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-01-05 | — | — | US | disclosed |
| US-5145855-A | Hypotensive, memory deficit, asthma, psorisis | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5093336-A | Treatment of cardiac failure and memory deficit | HOECHAT-ROUSSEL PHARMACEUTICALS, INC. (US) | 1992-03-03 | — | — | US | disclosed |
| US-4999351-A | Treating cardiac failure and memory deficit | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0406789-A1 | 6-and 7-Deoxyforskolin and derivates thereof, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| EP-0378159-A1 | 7-Aryl- and heteroaryl ethers of desacetylforskolin, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-07-18 | — | — | EP | disclosed |