Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.56 |
| ▸ | PLG | P00747 | 2/20 | 0.56 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 5/20 | 0.55 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787163 | 0.87 | F10 (0.55) | F10PLGPLAUF2HPN | |
| SCHEMBL6786044 | 0.85 | F10 (0.63) | F10PLGPLAUF2 | |
| SCHEMBL8721773 | 0.85 | F10 (0.63) | F10PLGPLAUF2 | |
| SCHEMBL8716427 | 0.84 | SLC1A3 (0.51) | F2 | |
| SCHEMBL27489065 | 0.81 | PLG (0.67) | F10PLGPLAUF2 | |
| Hydrochloric Acid SCHEMBL6793275 | 0.81 | PLG (0.66) | F10PLGPLAUF2 | |
| SCHEMBL6794066 | 0.78 | ACACB (0.54) | F10PLGPLAUF2 | |
| SCHEMBL8548180 | 0.77 | F10 (0.49) | F10PLGPLAUF2HPN | |
| SCHEMBL7395628 | 0.77 | GAA (0.48) | PLGPLAUF2 | |
| SCHEMBL3441384 | 0.77 | BDKRB1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |