Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.87 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306199 | 0.93 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7298995 | 0.90 | PDE5A (0.86) | PDE5A | |
| SCHEMBL7302518 | 0.85 | PDE5A (0.87) | PDE5A | |
| SCHEMBL719596 | 0.83 | PDE5A (1.00) | PDE5A | |
| SCHEMBL29612098 | 0.83 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7298811 | 0.83 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7367964 | 0.81 | PDE5A (0.79) | PDE5A | |
| SCHEMBL7299536 | 0.80 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7302290 | 0.79 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7299038 | 0.76 | PDE5A (0.80) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636626-A1 | Pyrazolopyrimidine Derivatives | LABORATOIRES GLAXO SA (FR) | 1995-02-01 | — | — | EP | disclosed |