Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138154 | 0.79 | KDM4E (0.39) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL8240200 | 0.77 | KDM4E (0.40) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL12128670 | 0.71 | KDM4E (0.36) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL14970370 | 0.67 | — | — | |
| SCHEMBL78087 | 0.67 | — | — | |
| SCHEMBL17674741 | 0.66 | — | — | |
| SCHEMBL15200246 | 0.65 | KDM4E (0.42) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL889022 | 0.65 | — | — | |
| SCHEMBL295249 | 0.65 | — | — | |
| SCHEMBL5597209 | 0.65 | KDM4E (0.48) | KDM4EMAPK1HIF1ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |