Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631173 | 0.84 | KAT2B (0.44) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL13236290 | 0.83 | TSHR (0.50) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL16129107 | 0.81 | TSHR (0.48) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL10756385 | 0.81 | TSHR (0.48) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL29800961 | 0.81 | TSHR (0.48) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL10761199 | 0.81 | TSHR (0.48) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL7466959 | 0.80 | TSHR (0.49) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL8385612 | 0.80 | TSHR (0.43) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL27801706 | 0.79 | TSHR (0.46) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL | |
| SCHEMBL9203388 | 0.78 | TSHR (0.58) | TSHRSMN1; SMN2CYP3A4ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1016175-B | Imidazoquinoline antithrombin cardiotonic agents | BRISTOL MYERS CO (US) | 1992-04-08 | — | — | CN | disclosed |
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |
| CN-86102747-A | The preparation method of imidazoquinoline antithombogehic cardiotonic agents | — | 1987-02-04 | — | — | CN | disclosed |
| US-RE31617-E | ANTICOAGULANTS; HYPOTENSIVE AND BRONCHODILATOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| US-3932407-A | BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTICOAGULANTS | BRISTOL-MYERS COMPANY (US) | 1976-01-13 | — | — | US | disclosed |