Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304341 | 0.90 | F2 (0.46) | F2AVPR1AALDH1A1CNR1CNR2 | |
| SCHEMBL8719765 | 0.90 | F2 (0.46) | F2AVPR1AALDH1A1CNR1CNR2 | |
| SCHEMBL7334523 | 0.86 | GAA (0.42) | F2ALDH1A1ACACBPOLBPLG | |
| SCHEMBL7305089 | 0.81 | ACACB (0.45) | F2ACACBF10PLGPLAT | |
| SCHEMBL7294588 | 0.81 | F2 (0.48) | F2ALDH1A1ACACBPOLBF10 | |
| SCHEMBL7306534 | 0.81 | F2 (0.47) | F2ACACB | |
| SCHEMBL7327272 | 0.78 | GAA (0.42) | F2ALDH1A1ACACBPLGPLAT | |
| SCHEMBL8716427 | 0.77 | SLC1A3 (0.51) | F2ALDH1A1ACACBPOLBKAT6A | |
| SCHEMBL8947835 | 0.77 | GAA (0.42) | F2ALDH1A1ACACBKAT6APLG | |
| SCHEMBL8947833 | 0.77 | F2 (0.55) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |