Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299672 | 0.93 | PDE3B (0.48) | PDE3BPDE3APDE2AHRH3MAPT | |
| SCHEMBL7295628 | 0.81 | PDE3B (0.46) | PDE3BPDE3APDE2AMAPTLMNA | |
| SCHEMBL7306629 | 0.78 | CYP1A2 (0.47) | PDE3BPDE3APDE2AHRH3MAPT | |
| SCHEMBL7303295 | 0.75 | PDE3B (0.44) | PDE3BPDE3APDE2AHRH3MAPT | |
| SCHEMBL7303102 | 0.73 | PDE3B (0.43) | PDE3BPDE3APDE2AMAPTPDE4A | |
| SCHEMBL7295569 | 0.73 | PDE3B (0.45) | PDE3BPDE3APDE2AMAPTLMNA | |
| SCHEMBL7307403 | 0.72 | PDE3B (0.50) | PDE3BPDE3AHRH3MAPTPDE4A | |
| SCHEMBL7275413 | 0.71 | PDE3B (0.47) | PDE3BPDE3APDE2AMAPTLMNA | |
| SCHEMBL4903296 | 0.70 | PDE3B (0.54) | PDE3BPDE3AHRH3MAPTLMNA | |
| SCHEMBL9877849 | 0.70 | PDE3B (0.43) | PDE3BPDE3AMAPTLMNANPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |