Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132345 | 0.85 | GAA (0.50) | CHRM2CHRM4CHRM1CHRM3SIGMAR1 | |
| SCHEMBL10076069 | 0.83 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3SIGMAR1 | |
| SCHEMBL28507625 | 0.83 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3SIGMAR1 | |
| SCHEMBL27147241 | 0.82 | PLA2G10 (0.41) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL3470166 | 0.82 | PLA2G10 (0.41) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL3799622 | 0.82 | PLA2G10 (0.41) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL7132777 | 0.81 | GAA (0.50) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL17294008 | 0.81 | USP2 (0.50) | CHRM2CHRM4CHRM1CHRM3DTYMK | |
| SCHEMBL3982519 | 0.81 | USP2 (0.50) | CHRM2CHRM4CHRM1CHRM3DTYMK | |
| SCHEMBL28509622 | 0.81 | CHRM2 (0.41) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |