Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.63 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30147198 | 0.88 | HTRA1 (0.66) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL2239296 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL4195796 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL5203691 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL5201925 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL1243964 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL205497 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL1782234 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL9543379 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 | |
| SCHEMBL5206918 | 0.86 | HTRA1 (0.60) | HTRA1ELANECYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |