Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24850734 | 0.81 | KDM4E (0.42) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL24851661 | 0.78 | KDM4E (0.39) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL8666209 | 0.77 | KDM4E (0.36) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL19838 | 0.75 | KDM4E (0.48) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL8025595 | 0.75 | KDM4E (0.48) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL11982090 | 0.75 | KDM4E (0.48) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL14378270 | 0.73 | EPHX1 (0.32) | SMN1; SMN2ALDH1A1EPHX1POLBCA2 | |
| SCHEMBL1704966 | 0.73 | MAPT (0.64) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL4701435 | 0.73 | MAPT (0.64) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL12064252 | 0.73 | MAPT (0.64) | SMN1; SMN2MAPTKDM4ETHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |