Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336984 | 0.87 | PDE4B (0.61) | PDE4BADORA1TSHRHTTLMNA | |
| SCHEMBL12027297 | 0.83 | PDE4B (0.51) | PDE4BADORA1ALDH1A1NPC1RAB9A | |
| SCHEMBL7315712 | 0.80 | PDE4B (0.60) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL8442353 | 0.78 | PDE4B (0.82) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7316395 | 0.77 | PDE4B (0.52) | PDE4BADORA1ALDH1A1RECQLHTT | |
| SCHEMBL7315521 | 0.77 | PDE4B (0.68) | PDE4BADORA1ALDH1A1TSHRMAPK1 | |
| SCHEMBL4061285 | 0.76 | NPC1 (0.47) | PDE4BADORA1ALDH1A1NPC1RAB9A | |
| SCHEMBL4053270 | 0.73 | SMN1; SMN2 (0.49) | PDE4BADORA1ALDH1A1HTTNPC1 | |
| SCHEMBL2826787 | 0.73 | HDAC1 (0.48) | ADORA1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL2824627 | 0.73 | PDE4B (0.53) | PDE4BADORA1ALDH1A1HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |