Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 7/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310878 | 0.93 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7307197 | 0.92 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7310780 | 0.88 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7307653 | 0.80 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7312710 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310459 | 0.78 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7319179 | 0.78 | LCK (0.36) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7351300 | 0.75 | LCK (0.36) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7311535 | 0.75 | MAPT (0.37) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7318898 | 0.75 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |