Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.59 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.57 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310103 | 0.90 | OPRL1 (0.61) | HTR1DOPRL1TRPV6TRPV5OPRM1 | |
| SCHEMBL7299616 | 0.87 | HTR1D (0.66) | HTR1DOPRL1POLBCCR3 | |
| SCHEMBL7040978 | 0.87 | OPRL1 (0.52) | HTR1DOPRL1TRPV6TRPV5OPRM1 | |
| SCHEMBL4778246 | 0.85 | OPRL1 (0.78) | OPRL1POLBCCR3GAAOPRM1 | |
| SCHEMBL7038207 | 0.85 | HTR1D (0.69) | HTR1DOPRL1TRPV6TRPV5 | |
| SCHEMBL7040756 | 0.82 | HTR1D (0.62) | HTR1DOPRL1POLBCCR3 | |
| SCHEMBL7305248 | 0.81 | HTR1D (0.57) | HTR1DOPRL1 | |
| SCHEMBL7038388 | 0.77 | HTR1D (0.88) | HTR1D | |
| SCHEMBL8192036 | 0.77 | HTR1D (0.88) | HTR1D | |
| SCHEMBL8192035 | 0.77 | HTR1D (0.88) | HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153611-A | AS NON-DOPAMINERGIC ANTIISCHEMIC COMPOUNDS FOR TREATING BRAIN DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| EP-0560669-B1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | BRISTOL MYERS SQUIBB CO (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0560669-A1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | Bristol-Myers Squibb Company (US) | 1993-09-15 | — | — | EP | disclosed |