Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312608 | 0.77 | HRH3 (0.42) | MAPTHTTSMN1; SMN2SPHK1GAA | |
| SCHEMBL33651 | 0.77 | MAPT (0.41) | MAPTHTTSMN1; SMN2SPHK1GAA | |
| SCHEMBL17988078 | 0.77 | MAPT (0.41) | MAPTHTTSMN1; SMN2SPHK1GAA | |
| SCHEMBL12126047 | 0.77 | MAPT (0.44) | MAPTHTTSMN1; SMN2SPHK1GAA | |
| SCHEMBL26929021 | 0.77 | MAPT (0.50) | MAPTHTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL28827422 | 0.77 | MAPT (0.41) | MAPTHTTSMN1; SMN2SPHK1GAA | |
| SCHEMBL1298434 | 0.76 | MAPT (0.61) | MAPTHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10755307 | 0.76 | CYP1A2 (0.46) | IDH2 | |
| SCHEMBL17988077 | 0.76 | MAPT (0.47) | MAPTHTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL13979947 | 0.75 | SPHK1 (0.54) | SPHK1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |