Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29804928 | 0.88 | PARP1 (0.46) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E | |
| SCHEMBL27703596 | 0.83 | PDPK1 (0.46) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E | |
| SCHEMBL4155293 | 0.79 | EGLN1 (0.57) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E | |
| SCHEMBL8852483 | 0.79 | KDM4E (0.42) | KDM4EDAOHPGD | |
| SCHEMBL4158228 | 0.77 | KDM5A (0.56) | KDM4EFEN1HPGD | |
| SCHEMBL11090377 | 0.75 | DAO (0.41) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E | |
| SCHEMBL8807295 | 0.74 | SLC22A12 (0.56) | KDM4E | |
| SCHEMBL1039795 | 0.73 | MAPT (0.59) | KDM4E | |
| SCHEMBL11090067 | 0.73 | DAO (0.40) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E | |
| SCHEMBL4700828 | 0.71 | KDM5A (0.50) | PARP1CSNK2A2CSNK2BCSNK2A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189240-A | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-05-28 | — | — | CN | disclosed |
| EP-0503844-B1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-03 | — | — | EP | disclosed |
| US-5155115-A | THIENOPYRIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0503844-A1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |