Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.56 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308822 | 0.98 | PDE4B (0.59) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7306806 | 0.97 | PDE4B (0.62) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7308807 | 0.95 | PDE4B (0.54) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7310479 | 0.94 | PDE4B (0.54) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7311580 | 0.93 | PDE4B (0.60) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7305094 | 0.93 | PDE4B (0.60) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7302079 | 0.92 | PDE4B (0.55) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7320289 | 0.91 | PDE4B (0.55) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7306144 | 0.90 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2ACRHR1 | |
| SCHEMBL7315409 | 0.90 | PDE4B (0.55) | PDE4BADORA1ADORA2BADORA2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |