Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | RAC1 | P63000 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305966 | 0.86 | PDE3B (0.57) | PDE3BPDE3APDE10AKDM4EGABRA1 | |
| SCHEMBL7318410 | 0.80 | PDE3B (0.46) | PDE3BPDE3APDE10AKDM4EGABRA1 | |
| SCHEMBL7317446 | 0.79 | TP53 (0.44) | PDE3BPDE3APDE10AKDM4EPOLB | |
| SCHEMBL7313861 | 0.77 | PDE3B (0.44) | PDE3BPDE3APDE10AKDM4EGABRA1 | |
| SCHEMBL7312543 | 0.76 | PDE10A (0.37) | PDE3BPDE3APDE10AKDM4EGABRA1 | |
| SCHEMBL7447294 | 0.75 | KDM4E (0.42) | PDE3BPDE3AKDM4EGABRA1GABRA5 | |
| SCHEMBL11971485 | 0.73 | PDE10A (0.56) | PDE3BPDE3APDE10AKDM4EPOLB | |
| SCHEMBL11971309 | 0.73 | PDE10A (0.56) | PDE3BPDE3APDE10AKDM4EMEN1 | |
| SCHEMBL6313239 | 0.73 | KDM4E (0.49) | PDE3BPDE3APDE10AKDM4EGAA | |
| SCHEMBL12325390 | 0.73 | CYP3A4 (0.46) | PDE3BPDE3AKDM4EGAARAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822800-A | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | claimed |