Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375765 | 0.87 | USP2 (0.55) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL24089120 | 0.81 | USP2 (0.50) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL16914459 | 0.79 | USP2 (0.50) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL20533859 | 0.79 | USP2 (0.45) | USP2SMN1; SMN2USP30KDM4EMAPT | |
| SCHEMBL16914257 | 0.78 | USP2 (0.45) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL18330214 | 0.78 | USP2 (0.45) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL23002557 | 0.78 | USP2 (0.45) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL16925372 | 0.78 | USP2 (0.45) | USP2SMN1; SMN2USP30RECQLKDM4E | |
| SCHEMBL5895323 | 0.78 | USP2 (0.47) | USP2SMN1; SMN2USP30KDM4EMAPT | |
| SCHEMBL9933565 | 0.77 | USP2 (0.48) | USP2SMN1; SMN2USP30RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |