Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.63 |
| ▸ | PDE4A | P27815 | 11/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.63 |
| ▸ | PDE5A | O76074 | 2/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394229 | 1.00 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7318009 | 0.92 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL8290599 | 0.92 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7312496 | 0.85 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7312504 | 0.85 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7311583 | 0.84 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL8924268 | 0.84 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7388415 | 0.84 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7312502 | 0.84 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7149565 | 0.84 | PDE4B (0.69) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0626957-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| EP-0626939-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014800-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994014742-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |