Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314807 | 0.90 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7310341 | 0.90 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7307752 | 0.89 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7321727 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310398 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7307255 | 0.80 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7317879 | 0.75 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10647542 | 0.74 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7309071 | 0.72 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7311541 | 0.72 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |