Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309937 | 0.95 | PDE4B (0.58) | PDE4BPOLBMEN1KMT2AADORA1 | |
| SCHEMBL7304940 | 0.90 | PDE4B (0.59) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7316395 | 0.89 | PDE4B (0.52) | PDE4BADORA1ADORA2AADORA2BRECQL | |
| SCHEMBL7314230 | 0.86 | PDE4B (0.52) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7308904 | 0.85 | PDE4B (0.56) | PDE4BMEN1KMT2AADORA1ADORA2A | |
| SCHEMBL7316210 | 0.85 | PDE4B (0.58) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7304693 | 0.85 | PDE4B (0.47) | PDE4BMEN1KMT2AADORA1ADORA2A | |
| SCHEMBL7303361 | 0.84 | PDE4B (0.49) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7308807 | 0.83 | PDE4B (0.54) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7310479 | 0.83 | PDE4B (0.54) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |