Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 5/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303561 | 0.96 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL7309398 | 0.96 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL1236129 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL1104912 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL12103325 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL691498 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL19261937 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL8222457 | 0.95 | KLK5 (0.61) | KLK5ATMBCHEBACE1PSEN1 | |
| SCHEMBL495728 | 0.94 | ATM (0.72) | KLK5ATMBCHEBACE1SLC6A11 | |
| SCHEMBL4809494 | 0.94 | ATM (0.72) | KLK5ATMBCHEBACE1SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559256-A | Aminediol protease inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0580402-A2 | Aminediol protease inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-01-26 | — | — | EP | disclosed |