Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2890971 | 1.00 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL10477647 | 1.00 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL28164924 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL28287041 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5350034 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL29089435 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL1092138 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL6265818 | 0.97 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL6265385 | 0.95 | CA4 (0.61) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5190913 | 0.94 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2711 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116553684-B | Device and method for electrochemical oxidation total denitrification of ammonia nitrogen wastewater | EAST CHINA JIAOTONG UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122017257-A | Detection method and detection kit for oxidized low-density lipoprotein | 济南玖方生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12576265-B2 | Conductive gel compositions and methods of production and use thereof | NOVOCURE GMBH (CH) | 2026-03-17 | — | — | US | claimed |
| US-20260060973-A1 | Ophthalmic Composition for Treating Non-Infectious Inflammatory Diseases | VIVAVISION BIOTECH LTD (CN) | 2026-03-05 | — | — | US | claimed |
| EP-4702974-A1 | OPHTHALMIC COMPOSITION CONTAINING VVN001 | Vivavision Biotech Ltd. (CN) | 2026-03-04 | — | — | EP | claimed |
| EP-4702973-A1 | OPHTHALMIC COMPOSITION FOR TREATING NON-INFECTIOUS INFLAMMATORY DISEASES | Vivavision Biotech Ltd. (CN) | 2026-03-04 | — | — | EP | claimed |
| US-20260022222-A1 | MICRO-FOAMING MASTERBATCH PELLET COMPOSITIONS FOR MICRO-FOAMED PLASTICS AND METHOD OF MANUFACTURING THE SAME | NANO & ADVANCED MATERIALS INST LTD (HK) | 2026-01-22 | — | — | US | claimed |
| CN-116550355-B | Preparation method of bimetallic site monoatomic catalyst and application of bimetallic site monoatomic catalyst in electrocatalytic ammoxidation total denitrification reaction | 华东交通大学 | 2025-06-13 | — | — | CN | claimed |
| US-12324871-B2 | Absorbable iron-based alloy implanted medical device and manufacturing method thereof | BIOTYX MEDICAL (SHENZHEN) CO., LTD. (CN) | 2025-06-10 | — | — | US | claimed |
| CN-120118400-A | Low-temperature-resistant flame-retardant rubber foam board and preparation method and application thereof | 中国科学院大连化学物理研究所 | 2025-06-10 | — | — | CN | claimed |
| US-4885279-A | ANTIINFLAMMATORY AGENTS; PREVENTING DAMAGE FROM DRUG USE | RAINSFORD KIM D (GB) | 1989-12-05 | — | — | US | claimed |
| US-4824664-A | ANTIHISTAMINES | LABORATOIRES SMITH KLINE & FRENCH (FR) | 1989-04-25 | — | — | US | claimed |
| EP-0154523-B1 | A PHARMACEUTICAL FORMULATION CONTAINING AZAPROPAZONE | Rainsford, Kim Drummond (GB) | 1989-03-22 | — | — | EP | claimed |
| EP-0239332-A2 | A pharmaceutical formulation containing indomethacin | Rainsford, Kim Drummond (CA) | 1987-09-30 | — | — | EP | claimed |
| EP-0154523-A2 | A pharmaceutical formulation containing azapropazone | Rainsford, Kim Drummond (GB) | 1985-09-11 | — | — | EP | claimed |
| EP-0011489-B1 | AN ANALGESIC EFFERVESCENT POWDER AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| US-4309408-A | ACETAMINOPHEN AND METOCLOPRAMIDE; ANALGESIC FOR MIGRAINE HEADACHES | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| EP-0011489-A1 | An analgesic effervescent powder and process for its preparation | BEECHAM GROUP PLC (GB) | 1980-05-28 | — | — | EP | claimed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |