Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22749227 | 0.83 | POLB (0.45) | POLBALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL12513697 | 0.83 | TP53 (0.40) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15935701 | 0.81 | TSHR (0.42) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL12071829 | 0.80 | TSHR (0.44) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL15681906 | 0.80 | TSHR (0.44) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL15935668 | 0.79 | TSHR (0.43) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL19123029 | 0.78 | TSHR (0.56) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL29497130 | 0.77 | TSHR (0.78) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL694640 | 0.77 | EPHX2 (0.40) | TSHRPOLBALDH1A1LMNAKMT2A | |
| Trifluoroacetic Acid SCHEMBL2680032 | 0.77 | DPP4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520336-A2 | Aldehyde derivatives and their use as calpain inhibitors | FUJIREBIO Inc. (JP) | 1992-12-30 | — | — | EP | disclosed |