Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310393 | 0.99 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7315430 | 0.88 | TSHR (0.60) | TSHRALDH1A1KDM4EPOLBHTR2C | |
| SCHEMBL7310908 | 0.79 | TSHR (0.54) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7532980 | 0.78 | KDM4E (0.54) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7310395 | 0.78 | TSHR (0.56) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL9082014 | 0.77 | KDM4E (0.53) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7421848 | 0.77 | KDM4E (0.53) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7421845 | 0.76 | TSHR (0.50) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7425021 | 0.75 | KMT2A (0.54) | TSHRSMN1; SMN2ALDH1A1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL7422558 | 0.74 | KDM4E (0.53) | TSHRSMN1; SMN2ALDH1A1LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |