Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 8/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.57 |
| ▸ | NOS2 | P35228 | 7/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306302 | 0.93 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| Hydrochloric Acid SCHEMBL7306045 | 0.91 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| Oxalic Acid SCHEMBL4936002 | 0.86 | SLC6A2 (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| Oxalic Acid SCHEMBL7317717 | 0.84 | SLC6A2 (0.60) | SLC6A2SLC6A4CYP2D6SLC6A3NOS2 | |
| Oxalic Acid SCHEMBL7310180 | 0.81 | FFAR1 (0.52) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| SCHEMBL5397302 | 0.80 | SLC6A2 (0.58) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| SCHEMBL5405164 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| SCHEMBL19668660 | 0.80 | SLC6A2 (0.62) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| SCHEMBL14415625 | 0.78 | SLC6A2 (0.50) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A | |
| SCHEMBL5397001 | 0.78 | SLC6A2 (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4313896-A | ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |