Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171835 | 0.87 | POLB (0.62) | KMT2APOLBCYP1A2CYP2C19LMNA | |
| SCHEMBL920392 | 0.87 | NSD2 (0.66) | KMT2APOLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4501918 | 0.86 | KMT2A (0.73) | KMT2ACYP1A2CYP2C19LMNAHPGD | |
| SCHEMBL1585174 | 0.85 | POLB (0.64) | KMT2APOLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL923044 | 0.83 | KMT2A (0.70) | KMT2ACYP1A2CYP2C19LMNAHPGD | |
| SCHEMBL21261436 | 0.83 | HPGD (0.70) | KMT2APOLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6905492 | 0.81 | POLB (0.56) | KMT2APOLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2735040 | 0.80 | KMT2A (0.87) | KMT2APOLBCYP1A2CYP2C19LMNA | |
| SCHEMBL15686619 | 0.80 | KMT2A (0.70) | KMT2ACYP1A2CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL12505487 | 0.79 | KMT2A (0.63) | KMT2ACYP1A2CYP2C19LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |