Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | RAC1 | P63000 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317441 | 0.83 | KDM4E (0.39) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL7305960 | 0.82 | KDM4E (0.38) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL6313239 | 0.79 | KDM4E (0.49) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL7309710 | 0.76 | KDM4E (0.46) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL7434923 | 0.76 | KDM4E (0.46) | KDM4ERAC1MEN1KMT2APOLB | |
| SCHEMBL7308411 | 0.76 | KDM4E (0.46) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| Bromide SCHEMBL7318711 | 0.73 | KDM4E (0.47) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL7318410 | 0.73 | PDE3B (0.46) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| SCHEMBL12325390 | 0.72 | CYP3A4 (0.46) | PDE3BPDE3AKDM4ERAC1MEN1 | |
| Hydrochloric Acid SCHEMBL27947697 | 0.72 | KDM4E (0.46) | PDE3BPDE3AKDM4ERAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822800-A | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | claimed |