Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309950 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL7312862 | 0.79 | POLB (0.53) | TSHRSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL6638827 | 0.79 | TSHR (0.57) | TSHRSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL391396 | 0.75 | POLB (0.68) | TSHRSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL24295874 | 0.74 | TSHR (0.62) | TSHRSMN1; SMN2EPHX2POLBALDH1A1 | |
| SCHEMBL29483537 | 0.74 | TSHR (0.66) | TSHRSMN1; SMN2EPHX2POLBALDH1A1 | |
| SCHEMBL29483527 | 0.74 | TSHR (0.62) | TSHRSMN1; SMN2EPHX2POLBALDH1A1 | |
| SCHEMBL24295449 | 0.74 | EPHX2 (0.75) | TSHRSMN1; SMN2EPHX2POLBALDH1A1 | |
| SCHEMBL7301268 | 0.74 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL29483541 | 0.73 | TSHR (0.68) | TSHRSMN1; SMN2POLBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |