Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 19/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731512 | 0.93 | TLR7 (0.59) | TLR7 | |
| SCHEMBL728851 | 0.91 | TLR7 (0.62) | TLR7 | |
| SCHEMBL729353 | 0.91 | TLR7 (0.59) | TLR7 | |
| SCHEMBL730748 | 0.91 | TLR7 (0.58) | TLR7 | |
| SCHEMBL730768 | 0.90 | TLR7 (0.63) | TLR7 | |
| SCHEMBL729242 | 0.89 | TLR7 (0.59) | TLR7 | |
| SCHEMBL4461136 | 0.89 | TLR7 (0.57) | TLR7 | |
| SCHEMBL729282 | 0.89 | TLR7 (0.62) | TLR7 | |
| SCHEMBL731478 | 0.89 | TLR7 (0.59) | TLR7 | |
| SCHEMBL734686 | 0.87 | TLR7 (0.67) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138172-B2 | 8-oxoadenine derivatives acting as modulators of TLR7 | ASTRAZENECA AB (SE) | 2012-03-20 | — | — | US | claimed |
| US-20100240623-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2010-09-23 | — | — | US | claimed |
| US-8138172-B2 | 8-oxoadenine derivatives acting as modulators of TLR7 | ASTRAZENECA AB (SE) | 2012-03-20 | — | — | US | disclosed |
| US-20100240623-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240623-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | TLR7, TLR8, TLR9 | TLR7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.