Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 1.00 |
| ▸ | GRM3 | Q14832 | 20/20 | 1.00 |
| ▸ | GRM6 | O15303 | 5/20 | 0.72 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.72 |
| ▸ | GRM8 | O00222 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063116 | 1.00 | GRM2 (1.00) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6788367 | 1.00 | GRM2 (1.00) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6791302 | 0.93 | GRM2 (0.86) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6916551 | 0.91 | GRM2 (0.84) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6916546 | 0.91 | GRM2 (0.84) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6906939 | 0.90 | GRM2 (0.83) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6906931 | 0.90 | GRM2 (0.83) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6794611 | 0.90 | GRM2 (1.00) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6906337 | 0.89 | GRM2 (0.80) | GRM2GRM3GRM6GRM4GRM8 | |
| SCHEMBL6906341 | 0.89 | GRM2 (0.80) | GRM2GRM3GRM6GRM4GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268507-B1 | USEFUL AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTION USEFUL AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTION | ELI LILLY AND COMPANY | 2001-07-31 | — | — | US | disclosed |
| EP-0878463-B1 | Excitatory amino acid receptor modulators | LILLY CO ELI (US) | 2000-12-20 | — | — | EP | disclosed |
| US-6160009-A | Excitatory amino acid receptor modulators | ELI LILLY AND COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0878463-A1 | Excitatory amino acid receptor modulators | ELI LILLY AND COMPANY (US) | 1998-11-18 | — | — | EP | disclosed |