Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.83 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.83 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.83 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650675 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316151 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316852 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7318809 | 0.89 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7313988 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Bromide SCHEMBL10665259 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7309152 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Bromide SCHEMBL7309492 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7313779 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10647577 | 0.89 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |