Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346052 | 0.93 | EPHX1 (0.49) | ITGB3ITGA2BEPHX1MEN1GAA | |
| SCHEMBL4520745 | 0.86 | EPHX1 (0.46) | ITGB3ITGA2BEPHX1MEN1GAA | |
| SCHEMBL3188767 | 0.86 | EPHX1 (0.46) | ITGB3ITGA2BEPHX1MEN1GAA | |
| SCHEMBL6957173 | 0.86 | EPHX1 (0.46) | ITGB3ITGA2BEPHX1MEN1GAA | |
| SCHEMBL7816567 | 0.85 | EPHX1 (0.48) | EPHX1MEN1GAAKMT2ATDP1 | |
| SCHEMBL16023429 | 0.84 | TDP1 (0.51) | EPHX1MEN1GAAKMT2ATDP1 | |
| SCHEMBL25122814 | 0.83 | TDP1 (0.54) | ITGB3ITGA2BEPHX1MEN1GAA | |
| Propionic Acid SCHEMBL16030396 | 0.83 | KMT2A (0.46) | ITGB3ITGA2BEPHX1MEN1GAA | |
| SCHEMBL12648114 | 0.82 | EPHX1 (0.55) | EPHX1MEN1GAAKMT2ATDP1 | |
| SCHEMBL25123076 | 0.82 | TDP1 (0.56) | EPHX1MEN1GAAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512829-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| US-5321034-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1994-06-14 | — | — | US | disclosed |
| EP-0512829-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |