Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 5/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318839 | 0.89 | MALT1 (0.52) | ELANECTSGMALT1TAAR1CMA1 | |
| SCHEMBL7313975 | 0.88 | MALT1 (0.51) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7355181 | 0.86 | MALT1 (0.59) | ELANEMALT1CMA1 | |
| SCHEMBL7316785 | 0.86 | ELANE (0.49) | ELANECTSGMALT1TAAR1CMA1 | |
| SCHEMBL7312695 | 0.85 | MALT1 (0.52) | ELANEMALT1CMA1 | |
| SCHEMBL7320551 | 0.85 | ELANE (0.40) | ELANEMALT1XIAPMLXMMP1 | |
| SCHEMBL7317461 | 0.83 | MALT1 (0.53) | ELANEMALT1CMA1 | |
| SCHEMBL7313441 | 0.82 | MALT1 (0.52) | ELANEMALT1CMA1MMP1MMP3 | |
| SCHEMBL7316711 | 0.82 | MALT1 (0.49) | ELANEMALT1TAAR1CMA1 | |
| SCHEMBL7312528 | 0.82 | MALT1 (0.51) | ELANEMALT1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |