Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 12/20 | 0.60 |
| ▸ | F2 | P00734 | 6/20 | 0.60 |
| ▸ | KLK1 | P06870 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 8/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301048 | 0.93 | PRSS1 (0.69) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7312732 | 0.88 | PRSS1 (0.59) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7312697 | 0.87 | PRSS1 (0.69) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7313912 | 0.86 | PRSS1 (0.61) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7313214 | 0.83 | PRSS1 (0.59) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL3242306 | 0.82 | PRSS1 (0.75) | PRSS1F2KLK1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7312895 | 0.82 | PRSS1 (0.73) | PRSS1F2KLK1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7312900 | 0.82 | PRSS1 (0.73) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7313716 | 0.82 | PRSS1 (0.64) | PRSS1F2KLK1MAPTKDM4E | |
| SCHEMBL7313722 | 0.82 | PRSS1 (0.64) | PRSS1F2KLK1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0543263-A2 | Benziimidazoles, pharmaceuticals containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-05-26 | — | — | EP | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |