Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881784 | 0.78 | POLB (0.45) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL17787695 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL2453964 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL3056784 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL12770947 | 0.72 | MEN1 (0.65) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL14495384 | 0.72 | KDM4C (0.62) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL6966371 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL11330176 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL31755975 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4ETDP1POLBAPEX1 | |
| SCHEMBL13564632 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4ETDP1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |