SCHEMBL7314614

SCHEMBL7314614

[CH2]c1ccccc1C#CC1CCCC1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.46
CYP1A2 P05177 1/20 0.46
KCNH2 Q12809 1/20 0.43
CREBBP Q92793 2/20 0.39
BRD4 O60885 1/20 0.39
FFAR1 O14842 2/20 0.34
FFAR4 Q5NUL3 2/20 0.34
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
PTPN11 Q06124 1/20 0.30
PAX8 Q06710 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11234197 0.77 GRM5 (0.46) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11230624 0.77 GRM5 (0.46) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11243818 0.77 CYP1A2 (0.46) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11236538 0.77 GRM5 (0.46) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11232054 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11235725 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11233698 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL9152622 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11235967 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4
SCHEMBL11246729 0.76 GRM5 (0.49) GRM5CYP1A2KCNH2CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US claimed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO claimed
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US disclosed