Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GALR3 | O60755 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307747 | 0.88 | PDE3B (0.60) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7314200 | 0.86 | MAPT (0.64) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7311327 | 0.86 | PDE3B (0.52) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11289838 | 0.83 | PDE3B (0.55) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7320976 | 0.82 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL16157001 | 0.82 | PDE3B (0.77) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10741604 | 0.82 | PDE3B (0.77) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7315150 | 0.82 | MAPT (0.50) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7314154 | 0.81 | PDE3B (0.55) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7310488 | 0.80 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |
| EP-0008391-A1 | Benzimidazoles, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1980-03-05 | — | — | EP | disclosed |