Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 9/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | THPO | P40225 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317021 | 0.94 | CACNA1F (0.50) | PDE1CCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7316659 | 0.91 | MAPT (0.60) | PDE1CCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7482705 | 0.88 | CACNA1F (0.51) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10368666 | 0.86 | CACNA1C (0.48) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10368670 | 0.86 | CACNA1C (0.48) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7309659 | 0.86 | CACNA1C (0.53) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10368228 | 0.86 | ABCB1 (0.48) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7309682 | 0.86 | CACNA1C (0.53) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10840034 | 0.86 | PDE1C (0.49) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10368230 | 0.86 | ABCB1 (0.48) | PDE1CCACNA1BCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177965-B1 | NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-03-21 | — | — | EP | disclosed |
| US-4705786-A | Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-11-10 | — | — | US | disclosed |
| EP-0177965-A2 | Novel oxa- and thiadiazolyl derivatives and their use | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |