Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319337 | 0.95 | PDE4B (0.52) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7318158 | 0.90 | PDE4B (0.66) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7310820 | 0.86 | PDE4B (0.59) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7308311 | 0.85 | PDE4B (0.66) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7313312 | 0.85 | PDE4B (0.55) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL12027312 | 0.85 | PDE4B (0.62) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7311318 | 0.83 | PDE4B (0.59) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7313916 | 0.83 | PDE4B (0.59) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7311591 | 0.83 | PDE4B (0.56) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4062757 | 0.83 | PDE4B (0.48) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |